MCU-i4, a mitochondrial Ca<sup>2+</sup> uniporter modulator, induces breast cancer BT474 cell death by enhancing glycolysis, ATP production and reactive oxygen species (ROS) burst
Cytotoxic mechanisms of MCU-i4 in cancer cells involved enhanced glycolysis and heightened formation of ATP and ROS. It is conventionally believed that cancer cell death could be caused by inhibition of glycolysis. Our observations suggest cancer cell death could also be induced by increased glycolytic metabolism.
Authors
- Edmund Cheung So (ORCID: https://orcid.org/0000-0002-2480-8843)
- Yuk‐Man Leung (ORCID: https://orcid.org/0000-0002-0626-1768)
- Ting‐Tsz Ou
- Chin-Min Chuang
- Yi‐Ping Huang (ORCID: https://orcid.org/0000-0003-0775-9880)
- Lian-Ru Shiao
- C. Chen
- Kar-Lok Wong
- Louis W.C. Chow
- Cheng-Hsun Wu
Institutions
- Dayeh University (TW)
- Providence University (TW)
- China Medical University (TW)
- Kuang Tien General Hospital (TW)
- An-Nan Hospital (TW)
- Unimed Medical Institute (CN)
- China Medical University Hospital (TW)
- Chang Jung Christian University (TW)
Publication Details
- Journal
- Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics
- Published
- 2024-08-26
- DOI
- https://doi.org/10.32604/or.2024.052743
- Citations
- 1
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.23
Funders
- China Medical University Hospital
- China Medical University
- Tainan Municipal An-Nan Hospital
- Division of Materials Research