Identification of active ingredients in Naomaitai capsules using high‐resolution mass spectrometry unite molecular network analysis and prediction of their action mechanisms
In conclusion, this study has revealed that NMC acts on multiple targets in the body through various active components, exerting synergistic effects in the treatment of CI. Its mechanism of action may involve inhibiting neuronal apoptosis, oxidative stress and inflammatory responses as well as reducing cerebral vascular permeability and promoting cerebral vascular regeneration.
Authors
- Zhiyan Liu (ORCID: https://orcid.org/0000-0001-9668-7756)
- Shuang Li (ORCID: https://orcid.org/0000-0002-8522-8527)
- Chenning Zhang (ORCID: https://orcid.org/0000-0002-3649-2428)
- Mo Sun (ORCID: https://orcid.org/0009-0000-7467-6490)
- Jinyu Fu
- Haiping Zeng
- Chun Bao
Institutions
- Hubei University of Medicine (CN)
- Georgia Institute of Technology (US)
- Kanion Pharmaceutical (China) (CN)
Publication Details
- Journal
- Rapid Communications in Mass Spectrometry
- Published
- 2024-08-26
- DOI
- https://doi.org/10.1002/rcm.9898
- Primary Topic
- Neurological Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Hubei Province