Redox-Neutral Coupling of Allyl Alcohols with Trifluoromethyl Ketones via Synergistic Ni–Ti Bimetallic Catalysis
A redox-neutral coupling of allyl alcohols with trifluoromethyl ketones has been developed via Ni-Ti bimetallic catalysis. This innovative method allows for the efficient synthesis of various β-tertiary trifluoromethyl alcohol-substituted ketones with yields of up to 98%. The reaction is scalable and compatible with a wide range of substrates, including complex bioactive molecules. Mechanistic studies suggest that the rate-determining step involving β-H elimination and the presence of the Ti-based Lewis acid, as well as a hydroxyl group on the substrates, is crucial for driving the reactivity of this transformation.
Authors
- Yong Li (ORCID: https://orcid.org/0000-0002-5081-6353)
- Lei Tang (ORCID: https://orcid.org/0000-0002-3167-226X)
- Jiang‐Fei Li
- Jiayu Huang (ORCID: https://orcid.org/0000-0001-5195-1330)
- Xiangkai Kong (ORCID: https://orcid.org/0000-0002-0552-5557)
- Rong‐Hua Wang
- Jianta Wang (ORCID: https://orcid.org/0000-0002-2007-0925)
- Bo Li (ORCID: https://orcid.org/0000-0001-7888-7519)
- Bin Liu (ORCID: https://orcid.org/0000-0003-2901-1013)
- Jiquan Zhang (ORCID: https://orcid.org/0000-0002-8034-7551)
- Siyu He (ORCID: https://orcid.org/0000-0001-7187-3034)
- Ming-Bai Gou
- Zhen-Qi Luo
- Qing He
Institutions
- Wannan Medical College (CN)
- Guiyang Medical University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-08-26
- DOI
- https://doi.org/10.1021/acs.orglett.4c02720
- Citations
- 8
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 2.00
Funders
- Health Commission of Guizhou Province
- National Natural Science Foundation of China
- Guizhou Medical University
- Science and Technology Program of Guizhou Province