CD64<sup>+</sup> fibroblast-targeted vilanterol and a STING agonist augment CLDN18.2 BiTEs efficacy against pancreatic cancer by reducing desmoplasia and enriching stem-like CD8<sup>+</sup> T cells
Vilanterol plus the STING agonist sensitised PDAC to CLDN18.2 BiTEs and augmented efficacy as a potential novel strategy.
Authors
- Chongbiao Huang (ORCID: https://orcid.org/0000-0001-9468-9168)
- Tiansuo Zhao (ORCID: https://orcid.org/0000-0003-1631-6299)
- Yiping Zou (ORCID: https://orcid.org/0000-0003-2880-2147)
- Yongjie Xie (ORCID: https://orcid.org/0009-0003-3595-0866)
- Jun Yu (ORCID: https://orcid.org/0000-0003-3435-6550)
- Xupeng Hou
- Xiuchao Wang (ORCID: https://orcid.org/0000-0002-3205-8544)
- Zhaoyu Zhang
- Jingrui Yan
- Xiufeng Zhang (ORCID: https://orcid.org/0000-0001-6707-3958)
- Jihui Hao (ORCID: https://orcid.org/0000-0002-1607-1730)
- Weiwei Bai
- Hongwei Wang (ORCID: https://orcid.org/0000-0003-3581-8892)
- Yifei Wang (ORCID: https://orcid.org/0000-0002-2073-2837)
- Hongxia Sun (ORCID: https://orcid.org/0000-0003-3229-4173)
- Li Lin (ORCID: https://orcid.org/0000-0003-2783-1114)
- Jing Liu (ORCID: https://orcid.org/0000-0002-8181-8159)
- Song Gao (ORCID: https://orcid.org/0000-0002-4587-5527)
- Xueyang Li (ORCID: https://orcid.org/0000-0001-8161-4781)
- Ziyun Liu (ORCID: https://orcid.org/0000-0003-2992-7590)
- Guohua Mao (ORCID: https://orcid.org/0000-0002-3664-1913)
- Wenna Jiang
- Bohang Xu
- Tianxing Zhou (ORCID: https://orcid.org/0009-0006-0150-1343)
Institutions
- Shanghai Medical College of Fudan University (CN)
- North China University of Science and Technology (CN)
- Chinese Academy of Sciences (CN)
- Tianjin Medical University Cancer Institute and Hospital (CN)
- Fudan University Shanghai Cancer Center (CN)
- Institute of Chemistry (CN)
Publication Details
- Journal
- Gut
- Published
- 2024-08-26
- DOI
- https://doi.org/10.1136/gutjnl-2024-332371
- Citations
- 14
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 3.37
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation