CD64<sup>+</sup> fibroblast-targeted vilanterol and a STING agonist augment CLDN18.2 BiTEs efficacy against pancreatic cancer by reducing desmoplasia and enriching stem-like CD8<sup>+</sup> T cells

Vilanterol plus the STING agonist sensitised PDAC to CLDN18.2 BiTEs and augmented efficacy as a potential novel strategy.

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Publication Details

Journal
Gut
Published
2024-08-26
DOI
https://doi.org/10.1136/gutjnl-2024-332371
Citations
14
Primary Topic
interferon and immune responses
Type
article
Field-Weighted Citation Impact
3.37

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article

CD64+ fibroblast-targeted vilanterol and a STING agonist augment CLDN18.2 BiTEs efficacy against pancreatic cancer by reducing desmoplasia and enriching stem-like CD8+ T cells

Chongbiao Huang, Tiansuo Zhao, Yiping Zou, Yongjie Xie et al.
14 citations
Gut
interferon and immune responses
3.37
article

CD64+ fibroblast-targeted vilanterol and a STING agonist augment CLDN18.2 BiTEs efficacy against pancreatic cancer by reducing desmoplasia and enriching stem-like CD8+ T cells

Chongbiao Huang, Tiansuo Zhao, Yiping Zou, Yongjie Xie, Jun Yu, Xupeng Hou, Xiuchao Wang, Zhaoyu Zhang, Jingrui Yan, Xiufeng Zhang, Jihui Hao, Weiwei Bai, Hongwei Wang, Yifei Wang, Hongxia Sun, Li Lin, Jing Liu, Song Gao, Xueyang Li, Ziyun Liu, Guohua Mao, Wenna Jiang, Bohang Xu, Tianxing Zhou
article en
14 citations

Abstract

Vilanterol plus the STING agonist sensitised PDAC to CLDN18.2 BiTEs and augmented efficacy as a potential novel strategy.

GutVol. 73(12)
Shanghai Medical College of Fudan University (CN), North China University of Science and Technology (CN), Chinese Academy of Sciences (CN), Tianjin Medical University Cancer Institute and Hospital (CN), Fudan University Shanghai Cancer Center (CN), Institute of Chemistry (CN)
National Natural Science Foundation of China, China Postdoctoral Science Foundation
Good health and well-being
Openalex Percentile: Top 7%
interferon and immune responses
3.37
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