Genetic association of antinuclear antibodies with HLA in JIA patients: a Swedish cohort study
This study identified distinct genetic associations between HLA alleles and JIA subtypes, particularly in ANA-positive patients. These findings contribute to a better understanding of the genetic basis of JIA and provide insights into the genetic control of autoantibody production in ANA-positive JIA patients. This may inform future classification and personalized treatment approaches for JIA, ultimately improving patient outcomes and management of this disease.
Authors
- Leonid Padyukov (ORCID: https://orcid.org/0000-0003-2950-5670)
- Raya Saleh (ORCID: https://orcid.org/0009-0001-0748-0794)
- Helena Erlandsson Harris (ORCID: https://orcid.org/0000-0002-7951-7509)
- Katarina Tengvall (ORCID: https://orcid.org/0000-0003-0424-3571)
- Erik Sundberg
- Ingrid Skelton Kockum (ORCID: https://orcid.org/0000-0002-0867-4726)
- Lars S. Alfredsson (ORCID: https://orcid.org/0000-0003-1688-6697)
- Mia Olsson (ORCID: https://orcid.org/0000-0002-7228-2575)
Institutions
- Karolinska University Hospital (SE)
- Karolinska Institutet (SE)
- University of Bergen (NO)
Publication Details
- Journal
- Pediatric Rheumatology
- Published
- 2024-08-26
- DOI
- https://doi.org/10.1186/s12969-024-01017-8
- Citations
- 1
- Primary Topic
- Autoimmune and Inflammatory Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 0.45
Funders
- Karolinska Institutet
- Reumatikerförbundet