Clinical phenotyping uncovers heterogeneous associations between corticosteroid treatment and survival in critically ill COVID-19 patients
Our multinational study identified three distinct clinical COVID-19 phenotypes, each exhibiting marked differences in demographic, clinical, and immunological features, and in the response to late and short-term corticosteroid treatment.
Authors
- Daniel Schwarzkopf (ORCID: https://orcid.org/0000-0002-1568-8202)
- Johannes G. van der Hoeven (ORCID: https://orcid.org/0000-0001-5362-0244)
- Daniel Thomas‐Rüddel (ORCID: https://orcid.org/0000-0001-9143-8566)
- Aron Jansen (ORCID: https://orcid.org/0000-0001-5158-0867)
- Eckart De Bie
- Jesús F. Bermejo-Martín (ORCID: https://orcid.org/0000-0002-7998-6268)
- Jason Kennedy (ORCID: https://orcid.org/0000-0001-7604-899X)
- Nicolette F. de Keizer (ORCID: https://orcid.org/0000-0002-6651-1730)
- Michael Bauer (ORCID: https://orcid.org/0000-0002-2666-859X)
- Dirk van Lier (ORCID: https://orcid.org/0000-0002-9176-4852)
- Niklas Bruse (ORCID: https://orcid.org/0000-0001-5146-5295)
- Matthijs Kox (ORCID: https://orcid.org/0000-0001-6537-6971)
- Lonneke van Vught
- Emma J. Kooistra (ORCID: https://orcid.org/0000-0001-5359-4840)
- Ana Motos (ORCID: https://orcid.org/0000-0002-3757-1232)
- Rombout Van Amstel
- Antoní Torres (ORCID: https://orcid.org/0000-0002-8643-2167)
- Christopher W. Seymour (ORCID: https://orcid.org/0000-0002-6257-6764)
- Ferrán Barbé (ORCID: https://orcid.org/0000-0001-8599-5497)
- Peter Pickkers
Institutions
- Radboud University Nijmegen (NL)
- University of Pittsburgh (US)
- Instituto de Salud Carlos III (ES)
- Amsterdam UMC Location University of Amsterdam (NL)
- Radboud University Medical Center (NL)
- Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (ES)
- Hospital Clínic de Barcelona (ES)
- Jena University Hospital (DE)
- Public Health Service of Amsterdam (NL)
- Amsterdam University Medical Centers (NL)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Universitat de Barcelona (ES)
- University of Amsterdam (NL)
Publication Details
- Journal
- Intensive Care Medicine
- Published
- 2024-08-26
- DOI
- https://doi.org/10.1007/s00134-024-07593-3
- Citations
- 21
- Primary Topic
- COVID-19 Clinical Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 8.17
Funders
- ZonMw
- European Society of Intensive Care Medicine