Cannabis sativa L. Extract Alleviates Neuropathic Pain and Modulates CB1 and CB2 Receptor Expression in Rat
Alterations in cannabinoid receptor expression do not fully account for the observed behavioural changes in rats. Therefore, additional signalling pathways may contribute to the initiation and transmission of neuropathic pain. The <i>Cannabis</i> extracts tested demonstrated antinociceptive effects comparable to gabapentin, highlighting the antinociceptive properties of <i>Cannabis</i> extracts for human use.
Authors
- Karolina Wielgus (ORCID: https://orcid.org/0000-0003-0629-2991)
- Radosław Kujawski (ORCID: https://orcid.org/0000-0002-2389-0689)
- Agnieszka Bienert (ORCID: https://orcid.org/0000-0001-7272-5738)
- Kamila Czora-Poczwardowska (ORCID: https://orcid.org/0000-0003-2873-4746)
- Małgorzata Jamka (ORCID: https://orcid.org/0000-0002-0257-6180)
- Ryszard Słomski (ORCID: https://orcid.org/0000-0001-5601-7002)
- Joanna Bartkowiak-Wieczorek (ORCID: https://orcid.org/0000-0002-8347-0512)
- Michał Szulc (ORCID: https://orcid.org/0000-0003-3295-2789)
- Marcin Hołysz (ORCID: https://orcid.org/0000-0003-2505-3582)
- Przemysław Ł. Mikołajczak (ORCID: https://orcid.org/0000-0002-1252-6523)
- Edyta Mądry (ORCID: https://orcid.org/0000-0002-0081-6558)
- Anna-Maria Wizner
Institutions
- Poznan University of Medical Sciences (PL)
- Institute of Natural Fibres and Medicinal Plants (PL)
Publication Details
- Journal
- Biomolecules
- Published
- 2024-08-26
- DOI
- https://doi.org/10.3390/biom14091065
- Citations
- 9
- Primary Topic
- Cannabis and Cannabinoid Research
- Type
- article
- Field-Weighted Citation Impact
- 4.03
Funders
- National Center for Research and Development