Molecular transmission network analysis reveals the challenge of HIV-1 in ageing patients in China: elderly people play a crucial role in the transmission of subtypes and high pretreatment drug resistance in developed Eastern China, 2019–2023
Our study revealed the important influence of elderly people on CRF07_BC transmission and the high prevalence of PDR. The clustering of drug-resistant cases was significant, which suggested the potential for localized widespread transmission of drug-resistant strains. HIV screening and the determination of PDR are recommended for older patients to improve early detection and reduce treatment failure and second-generation transmission.
Authors
- Dongqing Cao (ORCID: https://orcid.org/0000-0002-4778-3079)
- Tingting He (ORCID: https://orcid.org/0000-0001-6889-3333)
- Jingkun Chen (ORCID: https://orcid.org/0000-0001-9466-7153)
- Jiafeng Zhang (ORCID: https://orcid.org/0000-0003-4288-5516)
- Hui Xing
- Yi Feng
- Jiana Zhao
- Jiafeng Ling
Institutions
- Chinese Center For Disease Control and Prevention (CN)
- Shaoxing University (CN)
- Xian Center for Disease Control and Prevention (CN)
- Jiyang College of Zhejiang A&F University (CN)
- National Center for AIDS/STD Control and Prevention,China CDC (CN)
- Zhejiang Center for Disease Control and Prevention (CN)
- State Key Laboratory of Infectious Disease Prevention and Control
Publication Details
- Journal
- Virology Journal
- Published
- 2024-08-26
- DOI
- https://doi.org/10.1186/s12985-024-02455-2
- Citations
- 8
- Primary Topic
- HIV/AIDS Research and Interventions
- Type
- article
- Field-Weighted Citation Impact
- 3.11