Sex- and age-associated factors drive the pathophysiology of MASLD
Here, we show distinct responses to an HFD between males and females. Our study underscores the need for using both sexes in drug target identification studies, and characterizing the molecular mechanisms contributing to the MASLD pathophysiology in aging animals.
Authors
- Justin J. MacNeill (ORCID: https://orcid.org/0000-0002-6216-2174)
- Ajay K. Yadav (ORCID: https://orcid.org/0009-0009-4603-0081)
- Nadia Ashrafi
- Aleksei Krylov (ORCID: https://orcid.org/0000-0003-0055-5594)
- Núria Morral (ORCID: https://orcid.org/0000-0002-8932-2887)
- Stewart Francis Graham (ORCID: https://orcid.org/0000-0003-1001-0002)
- Sheng Liu (ORCID: https://orcid.org/0000-0001-5119-0324)
- Jun Wan (ORCID: https://orcid.org/0000-0001-9286-6562)
- Romana Ashrafi Mimi
- Romil Saxena (ORCID: https://orcid.org/0000-0002-1872-0431)
Institutions
- Emory University (US)
- Oakland University (US)
- Beaumont Hospital, Troy (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Hepatology Communications
- Published
- 2024-08-26
- DOI
- https://doi.org/10.1097/hc9.0000000000000523
- Citations
- 18
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 6.96
Funders
- School of Medicine, Indiana University