Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain
To improve the phenotype of tumor-directed T-cell therapy, we show that provision of cell-intrinsic IL7R-mediated signaling is preferable to activation of cells with exogenous IL7. We engineer this signaling via independent receptor engineering and incorporation into a CAR and validate maintained antigen-specific cytotoxic activity.
Authors
- Adam D. Fearnow
- Michael G. Leeming (ORCID: https://orcid.org/0000-0001-8981-0701)
- Jun Choe (ORCID: https://orcid.org/0000-0002-3389-5969)
- Scott T.R. Walsh (ORCID: https://orcid.org/0000-0002-9288-8443)
- Ruyan Rahnama (ORCID: https://orcid.org/0000-0003-3025-3546)
- Petya Apostolova (ORCID: https://orcid.org/0000-0002-3856-5109)
- Challice Lee Bonifant (ORCID: https://orcid.org/0000-0001-9028-1683)
- Jonas W. Ravich (ORCID: https://orcid.org/0000-0003-4770-0576)
- Erika L. Pearce (ORCID: https://orcid.org/0000-0001-5592-5439)
- Stamatia C. Vorri (ORCID: https://orcid.org/0000-0002-6100-1985)
- Natalie J. Holl (ORCID: https://orcid.org/0000-0001-8503-0839)
- Ravi Varadhan (ORCID: https://orcid.org/0000-0002-8434-1034)
- Ata Canbaz (ORCID: https://orcid.org/0000-0001-8782-7518)
- Arjun Modi
- Andrew Marple (ORCID: https://orcid.org/0000-0002-6724-8399)
Institutions
- National Institutes of Health (US)
- Bloomberg (United States) (US)
- Johns Hopkins University (US)
- The University of Melbourne (AU)
- Johns Hopkins Medicine (US)
- University Hospital of Basel (CH)
- National Cancer Institute (US)
- Sidney Kimmel Comprehensive Cancer Center (US)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2024-08-26
- DOI
- https://doi.org/10.1158/2767-9764.crc-24-0286
- Citations
- 4
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 1.13
Funders
- Bristol-Myers Squibb
- Johns Hopkins University
- Hyundai Hope On Wheels