Development and Application of SPOSiPs: A Class of Diphosphine Ligands Based on SPOSiOL
Here, we report the development and application of a novel class of spirosilacycle-based diphosphine ligands (SPOSiPs). This type of diphosphine ligand could be readily prepared in two steps with high efficiency starting from enantiopure spirobiphenoxasilin-diol (SPOSiOL). According to the structural analysis of SPOSiP and its PdCl<sub>2</sub> complex, SPOSiPs possess a flexible chiral pocket and feature a rigid configuration, a large dihedral angle, a long P-P distance, and a large P-M-P bite angle in their metal complexes. The potentials of SPOSiPs in asymmetric catalysis have also been preliminarily disclosed.
Authors
- Yichen Wu (ORCID: https://orcid.org/0000-0002-0639-0412)
- Junfei Luo (ORCID: https://orcid.org/0000-0001-5200-030X)
- Peng Wang (ORCID: https://orcid.org/0000-0002-6442-3008)
- Jianjun Li (ORCID: https://orcid.org/0000-0003-4122-8178)
- Fei Ren (ORCID: https://orcid.org/0000-0001-9876-0232)
- Zedong Li (ORCID: https://orcid.org/0000-0002-0643-3275)
Institutions
- Ningbo University (CN)
- Hangzhou Normal University (CN)
- Shanghai Institute of Organic Chemistry (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-08-26
- DOI
- https://doi.org/10.1021/acs.orglett.4c02784
- Citations
- 6
- Primary Topic
- Asymmetric Hydrogenation and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.95
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
- National Key Research and Development Program of China
- Program of Shanghai Academic Research Leader