A radioligand for in vitro autoradiography of CSF1R in post-mortem CNS tissues
Compound 1 exhibits a high in vitro CSF1R binding affinity. [<sup>11</sup>C]1 specifically labels CSF1R in the mouse neuroinflammation, but lacks the ability to efficiently cross the blood-brain barrier in baboon PET. [<sup>3</sup>H]1 specifically labels CSF1R in post-mortem human brain. The binding of [<sup>3</sup>H]1 is significantly higher in the post-mortem frontal cortex of AD versus control subjects.
Authors
- Il Minn (ORCID: https://orcid.org/0000-0002-7822-662X)
- Catherine A. Foss (ORCID: https://orcid.org/0000-0001-8870-5993)
- Andrew Hall (ORCID: https://orcid.org/0000-0002-6601-9009)
- Martin G. Pomper (ORCID: https://orcid.org/0000-0001-6753-3010)
- Paige Finley
- Ravi Naik
- Yong Du (ORCID: https://orcid.org/0000-0002-0237-6154)
- Hyojin Cha (ORCID: https://orcid.org/0000-0003-2262-7405)
- Deepankar Das (ORCID: https://orcid.org/0000-0003-4504-0367)
- Andrew G. Horti (ORCID: https://orcid.org/0000-0003-2290-488X)
- R. F. Dannals
- Sophia Jiang Wu
Institutions
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
Publication Details
- Journal
- EJNMMI Research
- Published
- 2024-08-26
- DOI
- https://doi.org/10.1186/s13550-024-01133-2
- Citations
- 3
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.74