A facile approach to the synthesis of 3,4-dihydro-2 <i>H</i> -benzo[4,5]imidazo[2,1-b][1,3,4]thiadiazines
An efficient approach to the synthesis of novel 2,3-diaryl-3,4-dihydro-2<i>H</i>-benzo[4,5]imidazo[2,1-b][1,3,4]thiadiazines via a base-catalyzed intramolecular cyclization of 2-arylmethylthio-<i>N</i>-arylidene-1<i>H</i>-benzo[d]imidazol-1-amines has been developed. The use of alkali is critical for the annulation of the thiadiazine ring. In the absence of strong bases, the starting compounds undergo deamination with elimination of benzonitrile and formation of 2-arylmethylthiobenzimidazoles.
Authors
- Alexandra A. Kolodina (ORCID: https://orcid.org/0000-0003-0485-7223)
- Evgenia S. Khodykina
- Diana Yu. Pobedinskaya (ORCID: https://orcid.org/0000-0002-4216-2521)
- А. В. Метелица (ORCID: https://orcid.org/0000-0003-3645-5528)
- I. G. Borodkina (ORCID: https://orcid.org/0000-0002-6682-4147)
- Олег П. Демидов (ORCID: https://orcid.org/0000-0002-3586-0487)
- Alexander V. Astakhov (ORCID: https://orcid.org/0000-0001-6926-8919)
- Victor M. Chernyshev (ORCID: https://orcid.org/0000-0001-9182-8564)
Institutions
- Southern Federal University (RU)
- North-Caucasus Federal University (RU)
- Platov South-Russian State Polytechnic University (RU)
Publication Details
- Journal
- Journal of Sulfur Chemistry
- Published
- 2024-08-26
- DOI
- https://doi.org/10.1080/17415993.2024.2394627
- Citations
- 1
- Primary Topic
- Synthesis and Characterization of Heterocyclic Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.25