Inhalable Stem Cell Exosomes Promote Heart Repair After Myocardial Infarction
In both rodent and swine models, our data proved the feasibility, efficacy, and general safety of SCENT treatment against acute MI injury, laying the groundwork for clinical investigation. Moreover, the EC-<i>Cd36</i><sup>fl/-</sup> mouse model provides the first in vivo evidence showing that conditional EC-CD36 knockout can ameliorate cardiac injury. Our study introduces a noninvasive treatment option for heart disease and identifies new potential therapeutic targets.
Authors
- Shiqi Hu (ORCID: https://orcid.org/0000-0002-8570-3439)
- Ke Cheng (ORCID: https://orcid.org/0000-0001-8053-7059)
- Halle Lutz (ORCID: https://orcid.org/0000-0001-6364-7627)
- Atul J. Butte (ORCID: https://orcid.org/0000-0002-7433-2740)
- Shenghuan Sun (ORCID: https://orcid.org/0000-0002-4339-2716)
- Dashuai Zhu (ORCID: https://orcid.org/0000-0002-4645-5786)
- Yuan Li (ORCID: https://orcid.org/0000-0002-1929-5465)
- Xuan Mei (ORCID: https://orcid.org/0000-0002-1190-0800)
- Kristen D. Popowski (ORCID: https://orcid.org/0000-0002-6341-2251)
- Ke Huang (ORCID: https://orcid.org/0000-0002-9355-7224)
- Phuong‐Uyen Dinh (ORCID: https://orcid.org/0000-0002-8969-6256)
- Shuo Liu (ORCID: https://orcid.org/0000-0002-2969-5876)
- Zhenzhen Wang (ORCID: https://orcid.org/0000-0002-5245-6726)
- Junlang Li (ORCID: https://orcid.org/0000-0002-5739-5168)
- Yongbo Lyu
Institutions
- University of North Carolina at Chapel Hill (US)
- Brigham and Women's Hospital (US)
- North Carolina State University (US)
- Columbia University Irving Medical Center (US)
- 490 BioTech (United States) (US)
- Columbia University (US)
Publication Details
- Journal
- Circulation
- Published
- 2024-08-26
- DOI
- https://doi.org/10.1161/circulationaha.123.065005
- Citations
- 93
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 21.75
Funders
- American Heart Association
- North Carolina State University