Synthesis, Structural Characterization, Anticancer, Antimicrobial, Antioxidant, and Computational Assessments of Zinc(II), Iron(II), and Copper(II) Chelates Derived From Selenated Schiff Base
ABSTRACT Novel selenated azomethine ligand (MSeOH) and its Zn(II), Fe(II), and Cu(II) chelates were synthesized. Their chemical structures were confirmed by molar conductivity, thermal analysis, X‐ray diffraction, IR, NMR, and MS spectroscopic techniques. The antitumor and antimicrobial properties were evaluated against various mammalian cells and pathogenic strains. Furthermore, the antioxidant activities were also assessed using DPPH and SOD bioassays. To gain a deeper understanding of the molecular structure and electronic properties of these complexes, a density functional theory (DFT) study was conducted. The parameters examined in this study provide valuable insight into the bonding, electronic properties, reactivity, and polarity of the compounds under investigation. The biological and theoretical results point to promising activities of the selenated ligand and its complexes.
Authors
- Tarek A. Yousef (ORCID: https://orcid.org/0000-0003-3039-7646)
- Ahmed S. Al‐Janabi (ORCID: https://orcid.org/0000-0003-2722-7419)
- Ghayah M. Alsulaim (ORCID: https://orcid.org/0000-0001-9390-7709)
- Saad Shaaban (ORCID: https://orcid.org/0000-0002-7835-6926)
- Ahmed M. Abu‐Dief (ORCID: https://orcid.org/0000-0003-3771-9011)
- Kamal Shalabi (ORCID: https://orcid.org/0000-0001-5478-6369)
- Mohamed Alaasar (ORCID: https://orcid.org/0000-0003-4155-8644)
- Hanan A. Althikrallah (ORCID: https://orcid.org/0000-0002-5098-3696)
- Khalid Tuama Abdullah
- Omar K. Al Duaij
Institutions
- Prince Sattam Bin Abdulaziz University (SA)
- Cairo University (EG)
- Mansoura University (EG)
- Taibah University (SA)
- Imam Mohammad ibn Saud Islamic University (SA)
- King Faisal University (SA)
- Martin Luther University Halle-Wittenberg (DE)
- University of Tikrit (IQ)
- University of Diyala (IQ)
- Sohag University (EG)
Publication Details
- Journal
- Applied Organometallic Chemistry
- Published
- 2024-08-26
- DOI
- https://doi.org/10.1002/aoc.7712
- Citations
- 39
- Primary Topic
- Metal complexes synthesis and properties
- Type
- article
- Field-Weighted Citation Impact
- 11.02
Funders
- Prince Sattam bin Abdulaziz University
- Al-Imam Muhammad Ibn Saud Islamic University
- King Faisal University