Cholangiocyte ciliary defects induce sustained epidermal growth factor receptor signaling
This study's findings shed light on ciliary function and robust EGFR signaling with slower receptor turnover. We could use therapies that restore the function of primary cilia to treat EGFR-driven diseases in polycystic liver disease and cholangiocarcinoma.
Authors
- Nicholas F. LaRusso (ORCID: https://orcid.org/0000-0003-3266-0831)
- Estanislao Peixoto (ORCID: https://orcid.org/0000-0001-5226-9747)
- Kishor Pant (ORCID: https://orcid.org/0000-0002-3505-6616)
- Seth Richard (ORCID: https://orcid.org/0000-0002-1143-7334)
- Sergio A. Gradilone (ORCID: https://orcid.org/0000-0002-1753-3634)
- Yanan Ren (ORCID: https://orcid.org/0000-0001-9586-3690)
- Tatyana V. Masyuk (ORCID: https://orcid.org/0000-0003-3290-9879)
- Rendong Yang (ORCID: https://orcid.org/0000-0002-9512-2240)
- Subheksha Baral
Institutions
- Northwestern University (US)
- University of Minnesota (US)
- Mayo Clinic (US)
- Hormel (United States) (US)
- University of Minnesota Medical Center (US)
Publication Details
- Journal
- Hepatology
- Published
- 2024-08-23
- DOI
- https://doi.org/10.1097/hep.0000000000001055
- Citations
- 11
- Primary Topic
- Pediatric Hepatobiliary Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 6.30
Funders
- Cholangiocarcinoma Foundation
- National Institutes of Health