The pattern of rpoB gene mutation of Mycobacterium tuberculosis and predictors of rifampicin resistance detected by GeneXpert MTB/RIF assay in Tanzania
The rate of RR was lower compared to other studies in Tanzania, with probe E mutations the most prevalent. Patients with disseminated TB, HIV co-infection and those with prior exposure to anti-TB had more risk of RR. The findings highlight the need to strengthen surveillance of multidrug-resistant TB among high risk patients.
Authors
- Riziki Kisonga (ORCID: https://orcid.org/0000-0001-6427-6987)
- Loveness Urio
- Agricola Joachim (ORCID: https://orcid.org/0000-0001-6639-5293)
- Mtebe Majigo (ORCID: https://orcid.org/0000-0003-3726-2816)
- Peter Richard Torokaa (ORCID: https://orcid.org/0009-0003-3843-3434)
- Robert Balama (ORCID: https://orcid.org/0009-0002-3605-7407)
- Heledy Kileo
- Mariam R. Mbwana
- Mariam C. Monah
- Sephord Saul Ntibabara (ORCID: https://orcid.org/0009-0001-4487-512X)
- Jasper Kimambo
- Paschal Seleman
- Collins Franklin
Institutions
- Ministry of Health and Social Welfare (TZ)
- Muhimbili University of Health and Allied Sciences (TZ)
Publication Details
- Journal
- PLoS ONE
- Published
- 2024-08-26
- DOI
- https://doi.org/10.1371/journal.pone.0296563
- Citations
- 5
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.95
Funders
- Muhimbili University of Health and Allied Sciences
- University of Health and Allied Sciences