The diagnostic performance of CA-125 for the detection of ovarian cancer in women from different ethnic groups: a cohort study of English primary care data
The introduction of ethnicity-specific thresholds may increase the specificity and PPVs of CA-125 in ovarian cancer detection at the expense of sensitivity, particularly for Asian and Black women. As such, we cannot recommend the use of ethnicity-specific thresholds for CA-125.
Authors
- Luke Mounce (ORCID: https://orcid.org/0000-0002-6089-0661)
- Sarah Bailey (ORCID: https://orcid.org/0000-0003-0020-4778)
- Garth Funston (ORCID: https://orcid.org/0000-0002-4156-6401)
- Gary Abel (ORCID: https://orcid.org/0000-0003-2231-5161)
- Liz Down (ORCID: https://orcid.org/0000-0002-2738-2710)
- Tanimola Martins (ORCID: https://orcid.org/0000-0001-5226-4073)
- Lucy Kirkland (ORCID: https://orcid.org/0000-0002-8321-5079)
- Jessica Watson (ORCID: https://orcid.org/0000-0002-8177-6438)
- Melissa Barlow (ORCID: https://orcid.org/0000-0002-0746-1868)
- Samuel WD Merriel (ORCID: https://orcid.org/0000-0003-2919-9087)
Institutions
- Queen Mary University of London (GB)
- University of Exeter (GB)
- University of Manchester (GB)
- University of Bristol (GB)
Publication Details
- Journal
- Journal of Ovarian Research
- Published
- 2024-08-26
- DOI
- https://doi.org/10.1186/s13048-024-01490-5
- Citations
- 5
- Primary Topic
- Ovarian cancer diagnosis and treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.69
Funders
- Cancer Research UK
- National Institute for Health and Care Research
- Department of Health and Social Care
- Science and Engineering Research Board