DNA polymerase swapping in Caudoviricetes bacteriophages
Replacement of the DNAP gene by one encoding a DNAP of a different family occurred on many independent occasions during the evolution of different families of tailed phages, in some cases, resulting in very closely related phages encoding unrelated DNAPs. DNAP swapping was likely driven by selection for avoidance of host antiphage mechanisms targeting the phage DNAP that remain to be identified, and/or by selection against replicon incompatibility.
Authors
- Yuri I. Wolf (ORCID: https://orcid.org/0000-0002-0247-8708)
- Igor Tolstoy (ORCID: https://orcid.org/0009-0005-3854-9562)
- Mart Krupovìč (ORCID: https://orcid.org/0000-0001-5486-0098)
- Pascal Mutz (ORCID: https://orcid.org/0000-0002-0430-2095)
- Natalya Yutin (ORCID: https://orcid.org/0000-0002-3633-5123)
- Eugene V. Koonin
Institutions
- National Institutes of Health (US)
- Institut Pasteur (FR)
- Université Paris Cité (FR)
- National Center for Biotechnology Information (US)
Publication Details
- Journal
- Virology Journal
- Published
- 2024-08-26
- DOI
- https://doi.org/10.1186/s12985-024-02482-z
- Citations
- 6
- Primary Topic
- Bacteriophages and microbial interactions
- Type
- article
- Field-Weighted Citation Impact
- 2.75
Funders
- National Institutes of Health