miRNA omics reveal neferine induces apoptosis through Ca2+mediated endoplasmic reticulum stress pathway in human endometrial cancer
Nef could block the cell cycle and induce the activation of the mitochondrial apoptotic pathway involving the Ca<sup>2+</sup>-mediated ERS pathway and the PI3K/AKT pathway, thereby inducing apoptosis in EC cells, confirming the potential role of Nef in the prevention and treatment of EC.
Authors
- Feifei Ma (ORCID: https://orcid.org/0000-0003-1321-5564)
- Zhao‐Jun Wei (ORCID: https://orcid.org/0000-0003-1729-209X)
- Jian‐Guo Zhang (ORCID: https://orcid.org/0000-0001-6020-6148)
- Run‐Hui Ma
- Jesús Simal‐Gándara (ORCID: https://orcid.org/0000-0001-9215-9737)
- Kiran Thakur (ORCID: https://orcid.org/0000-0001-8441-6537)
- Hui Cao (ORCID: https://orcid.org/0009-0005-0283-3289)
Institutions
- Hefei University of Technology (CN)
- Anhui University of Science and Technology (CN)
- Universidade de Vigo (ES)
Publication Details
- Journal
- Phytomedicine
- Published
- 2024-08-26
- DOI
- https://doi.org/10.1016/j.phymed.2024.155988
- Citations
- 12
- Primary Topic
- Chromatography in Natural Products
- Type
- article
- Field-Weighted Citation Impact
- 2.83
Funders
- Universidade de Vigo
- National Key Research and Development Program of China
- Major Science and Technology Projects in Anhui Province