CCN4 (WISP-1) reduces apoptosis and atherosclerotic plaque burden in an ApoE mouse model
We conclude that in an atherosclerosis model the most important action of CCN4 is the effect on cell apoptosis. CCN4 provides pro-survival signals and leads to reduced cell death, lower macrophage number, smaller lipid core size and reduced atherosclerotic plaque burden. As such, the pro-survival effect of CCN4 is worthy of further investigation, in a bid to find a therapeutic for atherosclerosis.
Authors
- Rosaria Bianco
- Tessa Forbes (ORCID: https://orcid.org/0000-0003-0330-3229)
- Sarah J. George (ORCID: https://orcid.org/0000-0002-1426-8257)
- Steven J. Simmonds (ORCID: https://orcid.org/0000-0002-6750-5623)
- Jason L. Johnson (ORCID: https://orcid.org/0000-0003-0630-9183)
- Alexandros Somos (ORCID: https://orcid.org/0000-0003-0146-5742)
- Andrew Bond (ORCID: https://orcid.org/0000-0002-4255-4488)
- Ze Li (ORCID: https://orcid.org/0000-0003-2479-5381)
- Helen Williams (ORCID: https://orcid.org/0000-0003-3467-3054)
- Zoe Ann Brown (ORCID: https://orcid.org/0000-0001-6559-8486)
- Helen Rice
- Celyn Dugdale
- Andrew Herman
Institutions
- University of Bristol (GB)
- NIHR Bristol Cardiovascular Biomedical Research Unit (GB)
- KU Leuven (BE)
Publication Details
- Journal
- Atherosclerosis
- Published
- 2024-08-26
- DOI
- https://doi.org/10.1016/j.atherosclerosis.2024.118570
- Citations
- 1
- Primary Topic
- Connective Tissue Growth Factor Research
- Type
- article
- Field-Weighted Citation Impact
- 0.23
Funders
- British Heart Foundation
- National Institutes of Health