Total Synthesis of the Dimeric Phytocannabinoid Cannabitwinol (CBD Dimer) and Its Analogues
A new synthetic route to access the natural product phytocannabinoid cannabitwinol (<b>1</b>) starting from commercially available raw materials is disclosed. We have also demonstrated the synthesis of other related dimers, including their enantiomers, using the present sequence. This route avoids the legal constraints concerning the acquisition of cannabis plant material or CBD.
Authors
- D. Srinivasa Reddy (ORCID: https://orcid.org/0000-0003-3270-315X)
- Sanket S. Shete
- Anup Kumar Mondal
Institutions
- Indian Institute of Chemical Technology (IN)
- Academy of Scientific and Innovative Research (IN)
Publication Details
- Journal
- Journal of Natural Products
- Published
- 2024-08-26
- DOI
- https://doi.org/10.1021/acs.jnatprod.4c00674
- Citations
- 1
- Primary Topic
- Cannabis and Cannabinoid Research
- Type
- article
- Field-Weighted Citation Impact
- 0.45
Funders
- Council of Scientific and Industrial Research, India
- Science and Engineering Research Board