Phyllanretiosides A and B: Two Undescribed Compounds from <i>Phyllanthus Reticulatus</i> with Nitric Oxide Production Inhibition and Antimicrobial Activity
Phytochemical study on the methanol extract of the leaves of Phyllanthus reticulatus led to the isolation of two new compounds, phyllanretiosides A (1) and B (2) together with ten known ones (3-12). Their chemical structures were determined by HR-ESI-MS, NMR, and ECD spectra in comparison with the literature. Three ellagitannins, phyllanretioside A (1), corilagin (3), and phyllanthusiin C (4) inhibited lipopolysaccharide(LPS)-induced nitric oxide production in RAW 264.7 cells with IC<sub>50</sub> values of 63.2, 83.2, and 5.6 μM, respectively. In addition, compounds 1, 3, and 4 exhibited significantly antimicrobial activity (MICs: 16-128 μg/mL) towards some of seven microbial strains.
Authors
- Ngo Anh Bang
- Phan Văn Kiệm (ORCID: https://orcid.org/0000-0003-0756-6990)
- Bùi Hữu Tài (ORCID: https://orcid.org/0000-0002-2034-3786)
- Đỗ Thị Trang (ORCID: https://orcid.org/0000-0002-8378-1038)
- Dương Thị Dung (ORCID: https://orcid.org/0000-0001-6948-2333)
- Dương Thị Hải Yến (ORCID: https://orcid.org/0009-0000-8530-4457)
- Anh Tuấn Lê (ORCID: https://orcid.org/0000-0002-5917-3243)
- Nguyễn Huy Hoàng
- Phạm Hải Yến
- Phan Thị Thanh Hương
Institutions
- Cat Tien National Park (VN)
- Vietnam Academy of Science and Technology (VN)
Publication Details
- Journal
- Chemistry & Biodiversity
- Published
- 2024-08-26
- DOI
- https://doi.org/10.1002/cbdv.202401608
- Primary Topic
- Phytochemistry and Bioactivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Vietnam Academy of Science and Technology