Multi‐omics integration reveals the oncogenic role of eccDNAs in diffuse large B‐cell lymphoma through STING signalling
EccDNAs induced by DNA damage exert an oncogenic role in DLBCL via activating the STING signalling independently of cGAS. The combined treatment of chemotherapeutic drugs with STING inhibitor significantly delayed the tumor progression, providing new insights into the therapeutic strategy for patients with DLBCL, particularly the relapsed and/or refractory (R/R) ones.
Authors
- Yan Jiang (ORCID: https://orcid.org/0000-0001-6153-1997)
- Zijuan Wu (ORCID: https://orcid.org/0000-0001-8607-7858)
- Luqiao Wang (ORCID: https://orcid.org/0000-0003-0263-9492)
- Jia‐yan Leng
- Wenyu Shi (ORCID: https://orcid.org/0000-0002-2371-3332)
- Yongning Jiang
- Jianxin Fu (ORCID: https://orcid.org/0000-0002-3067-8539)
- Yongle Li (ORCID: https://orcid.org/0000-0001-9879-0626)
- Wei Zhang (ORCID: https://orcid.org/0000-0003-2934-060X)
- Jianyong Li (ORCID: https://orcid.org/0000-0002-9931-4055)
- Fan Zhou (ORCID: https://orcid.org/0000-0002-0616-3877)
- Lei Cao (ORCID: https://orcid.org/0000-0002-8015-4741)
- Hui Jin (ORCID: https://orcid.org/0000-0003-0297-3052)
- Bing Sun
- Mengtao Zhan
Institutions
- Jiangsu University (CN)
- Nantong University (CN)
- Sir Run Run Shaw Hospital (CN)
- Soochow University (CN)
- Affiliated Hospital of Nantong University (CN)
- Affiliated Hospital of Jiangsu University (CN)
- Jiangsu Province Hospital (CN)
- First Affiliated Hospital of Soochow University (CN)
- Zhejiang University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2024-08-01
- DOI
- https://doi.org/10.1002/ctm2.1815
- Citations
- 5
- Primary Topic
- Lymphoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.12
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangsu Province