Integrating surgical intervention and watch-and-wait approach in dMMR metastatic rectal cancer with pembrolizumab: a case report
The WW strategy is increasingly accepted for patients achieving cCR after preoperative treatment. While pCR in dMMR rectal cancer patients treated with immune checkpoint inhibitors (ICIs) has been documented, accurately predicting pCR from imaging remains challenging. This case illustrates that integrating ICI therapy, surgical interventions, and the WW approach can effectively achieve both oncological safety and improved QOL in the treatment of dMMR metastatic rectal cancer.
Authors
- Takashi Akiyoshi (ORCID: https://orcid.org/0000-0002-2321-1412)
- Shimpei Matsui (ORCID: https://orcid.org/0000-0001-7509-9365)
- Tsubasa Sakurai (ORCID: https://orcid.org/0000-0002-7731-6383)
- Toshiki Mukai (ORCID: https://orcid.org/0000-0002-3553-3590)
- Izuma Nakayama (ORCID: https://orcid.org/0000-0003-4987-1934)
- Tomohiro Yamaguchi (ORCID: https://orcid.org/0000-0002-5023-0985)
- Atsushi Oba
- Akiko Chino (ORCID: https://orcid.org/0000-0001-7412-4397)
- Yosuke Fukunaga (ORCID: https://orcid.org/0000-0002-6397-0907)
- Kosuke Ozaki (ORCID: https://orcid.org/0000-0002-2775-2259)
- Yasuyuki Shigematsu (ORCID: https://orcid.org/0000-0001-5142-2906)
- Yohei Ando
Institutions
- Japanese Foundation For Cancer Research (JP)
Publication Details
- Journal
- Surgical Case Reports
- Published
- 2024-08-26
- DOI
- https://doi.org/10.1186/s40792-024-01994-8
- Citations
- 4
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.70