Neurodegenerative biomarkers in different chambers of the eye relative to plasma: an agreement validation study
AD biomarkers are detectable in greater quantities in eye fluids than in plasma and show correlations with levels in plasma. Future studies are needed to assess the utility of ocular fluid biomarkers as diagnostic and prognostic markers for AD, especially in those at risk with eye disease.
Authors
- Nurgül Aytan (ORCID: https://orcid.org/0000-0002-8974-5521)
- Thor D. Stein (ORCID: https://orcid.org/0000-0001-6954-4477)
- Steven Ness (ORCID: https://orcid.org/0000-0002-5843-9476)
- Manju L. Subramanian (ORCID: https://orcid.org/0000-0002-0061-098X)
- Nicole H. Siegel (ORCID: https://orcid.org/0000-0002-3523-8225)
- Konstantina Sampani (ORCID: https://orcid.org/0000-0002-6570-328X)
- Michael L. Alosco (ORCID: https://orcid.org/0000-0002-8113-8428)
- Fatima Tuz‐Zahra (ORCID: https://orcid.org/0000-0003-1763-255X)
- Xuejing Chen (ORCID: https://orcid.org/0000-0001-6827-0152)
- Sreevardhan Alluri
- Weiming Xia (ORCID: https://orcid.org/0000-0002-7463-3295)
- Yorghos Tripodis (ORCID: https://orcid.org/0000-0003-2190-7608)
- Elizabeth E. Spurlock
Institutions
- Boston University (US)
- Boston Medical Center (US)
- Joslin Diabetes Center (US)
- Harvard University (US)
- University of Arizona (US)
- Edith Nourse Rogers Memorial Veterans Hospital (US)
- VA Boston Healthcare System (US)
- Bedford VA Research Corporation (US)
- VA New England Healthcare System (US)
- Geriatric Research Education and Clinical Center (US)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2024-08-26
- DOI
- https://doi.org/10.1186/s13195-024-01556-y
- Citations
- 20
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 6.53
Funders
- U.S. Department of Veterans Affairs
- National Institutes of Health
- National Institute on Aging