Preclinical pharmacokinetic studies and prediction of human PK profiles for Deg-AZM, a clinical-stage new transgelin agonist
The pharmacokinetic profiles of Deg-AZM was fully explored, these results could provide valuable information to support the first-in-human dosage prediction and phase I clinical design.
Authors
- Xiaoyu Ai (ORCID: https://orcid.org/0000-0003-3113-0118)
- Cheng Yang (ORCID: https://orcid.org/0000-0001-9431-290X)
- Yao Sun (ORCID: https://orcid.org/0000-0002-6519-7436)
- Weixue Tian
- Shuwen Zhu
- Honggang Zhou (ORCID: https://orcid.org/0000-0003-2987-3422)
- Xiang Xu (ORCID: https://orcid.org/0000-0003-4822-9595)
- Hongting Liu (ORCID: https://orcid.org/0000-0002-1224-485X)
- Zhilin Luo
- Xiaoting Gu
- Xiaohe Li (ORCID: https://orcid.org/0000-0003-1552-6243)
- Conglu Zhao
- Yutian Cai
- Chaoyue Zheng
Institutions
- Nankai University (CN)
- National Institutes of Pharmaceutical Research and Development (China) (CN)
- Tianjin International Joint Academy of Biomedicine (CN)
- State Key Laboratory of Medicinal Chemical Biology
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-08-26
- DOI
- https://doi.org/10.3389/fphar.2024.1423175
- Citations
- 1
- Primary Topic
- Drug Transport and Resistance Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.28
Funders
- National Natural Science Foundation of China
- Nankai University
- Natural Science Foundation of Tianjin City
- Fundamental Research Funds for the Central Universities