Shikonin from <i>lithospermum erythrorhizon</i> induces pyroptosis in trophoblast cells by activating the CTSB-NLRP3 inflammasome
Our results suggest that shikonin activates CTSB to induce NLRP3-dependent pyroptosis in HTR-8/SVneo cells. This study has important clinical implications for the treatment of ectopic pregnancy.
Authors
- Fuling Zeng (ORCID: https://orcid.org/0000-0001-9689-5440)
- Shuo Yuan
- Gaopi Deng (ORCID: https://orcid.org/0000-0002-8380-0761)
- Pin Qiu
- Zhenyue Chen (ORCID: https://orcid.org/0000-0001-9508-7521)
- Jie Gao (ORCID: https://orcid.org/0000-0003-1317-2445)
- Min Feng (ORCID: https://orcid.org/0000-0002-9062-8074)
- Lihua Zeng (ORCID: https://orcid.org/0000-0002-3196-6401)
- Yu‐Ling Lai (ORCID: https://orcid.org/0000-0001-7708-3850)
- Yanxi Huang
- Fangfang Zhu
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Guangzhou Sport University (CN)
- First Affiliated Hospital of Guangzhou University of Chinese Medicine (CN)
Publication Details
- Journal
- Annals of Medicine
- Published
- 2024-08-25
- DOI
- https://doi.org/10.1080/07853890.2024.2394584
- Citations
- 4
- Primary Topic
- Pregnancy-related medical research
- Type
- article
- Field-Weighted Citation Impact
- 2.17
Funders
- National Natural Science Foundation of China
- Guangzhou University of Chinese Medicine
- Guangzhou University