Poly(ethylene glycol) patterned surfaces functionalized with gallic acid@Au nanoparticles: investigation of antibacterial activity for biomedical applications

Abstract Polymer patterns are promising for many applications due to their high stability and superior chemical and physical properties. By functionalizing various surfaces with polymer patterns, it is possible to detect and prevent many common infections. Treatment of resistant bacteria with antibiotics is limited and they can spread quickly. For this reason, it was designed a surface that can prevent contamination by functionalizing polymer patterns. In the study, a polymer pattern model obtained by combining gallic acid with gold nanoparticles (GA@AuNP) synthesized through green chemistry was designed. Polymer-patterned structures were obtained on silicon wafers using Poly(ethylene glycol) (PEG) polymer and were self-assembled with GA@AuNPs. Diagnosis and inhibition of bacterial cells in a short time were demonstrated with the prepared modified PEG polymer pattern. Surface-enhanced Raman scattering effects were used to optimize the stability of surfaces patterned with self-assembled GA@Au NPs. By modification of PEG polymer patterns, a biomarker design that can be used in many different bioapplications is proposed.