KCNJ16-depleted kidney organoids recapitulate tubulopathy and lipid recovery upon statins treatment
Mature kidney organoids represent a relevant in vitro model for investigating the function of Kir5.1. We discovered novel molecular targets for this genetic tubulopathy and identified statins as a potential therapeutic strategy for KCNJ16 defects in the kidney.
Authors
- Manoe J. Janssen (ORCID: https://orcid.org/0000-0002-0544-8096)
- Joost G.J. Hoenderop (ORCID: https://orcid.org/0000-0002-1816-8544)
- Jeroen H. F. de Baaij (ORCID: https://orcid.org/0000-0003-2372-8486)
- Rosalinde Masereeuw (ORCID: https://orcid.org/0000-0002-1560-1074)
- Elena Sendino Garví (ORCID: https://orcid.org/0000-0001-9378-3670)
- Anne Metje van Genderen (ORCID: https://orcid.org/0000-0001-9643-7722)
- Esther A. Zaal (ORCID: https://orcid.org/0000-0001-9890-7345)
- Gijs Jacobus Johannes van Slobbe
Institutions
- Radboud University Nijmegen (NL)
- Utrecht University (NL)
- Radboud University Medical Center (NL)
- Pharmo Institute (NL)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2024-08-26
- DOI
- https://doi.org/10.1186/s13287-024-03881-3
- Citations
- 4
- Primary Topic
- Renal and related cancers
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Health~Holland
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Radboud Universitair Medisch Centrum