G-quadruplexes as pivotal components of cis-regulatory elements in the human genome
Our study suggests that G4s are integral components of human cis-regulatory elements, extending beyond their potential role in promoters. The G4 primary sequences are associated with the localization of CREs, while the G4 structures are linked to the activation of these elements. Therefore, we propose defining G4s as pivotal regulatory elements in the human genome.
Authors
- Jean‐Louis Mergny (ORCID: https://orcid.org/0000-0003-3043-8401)
- Cheng Wang (ORCID: https://orcid.org/0000-0002-8193-9276)
- Yuqi Wang (ORCID: https://orcid.org/0000-0003-1200-3885)
- Xiao Sun (ORCID: https://orcid.org/0000-0003-1048-7775)
- Rongxin Zhang (ORCID: https://orcid.org/0000-0002-1643-1185)
Institutions
- Centre National de la Recherche Scientifique (FR)
- École Polytechnique (FR)
- Inserm (FR)
- Southeast University (BD)
- State Key Laboratory of Digital Medical Engineering (CN)
- Southeast University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- BMC Biology
- Published
- 2024-08-25
- DOI
- https://doi.org/10.1186/s12915-024-01971-5
- Citations
- 14
- Primary Topic
- DNA and Nucleic Acid Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 3.27
Funders
- Agence Nationale de la Recherche
- National Natural Science Foundation of China
- Government of Jiangsu Province
- China Scholarship Council
- Institut National Du Cancer