Discovering genes and microRNAs involved in human lung development unveils IGFBP3/miR-34a dynamics and their relevance for alveolar differentiation
The IGFBP3/miR-34a axis restricts IGFBP3 expression in the embryonic undifferentiated lung epithelium, and the progressive downregulation of IGFBP3 during the pseudoglandular stage is required for alveolar differentiation.
Authors
- Yangyi He (ORCID: https://orcid.org/0000-0003-0792-193X)
- Joan J. Castellano (ORCID: https://orcid.org/0000-0001-5836-565X)
- Tania Díaz (ORCID: https://orcid.org/0000-0001-9576-8351)
- Melissa Acosta-Plasencia (ORCID: https://orcid.org/0000-0001-6679-8869)
- Alfonso Navarro‐Ródenas (ORCID: https://orcid.org/0000-0001-9123-4547)
- Ramón M. Marrades (ORCID: https://orcid.org/0000-0001-9724-931X)
Institutions
- Columbia University Irving Medical Center (US)
- Instituto de Salud Carlos III (ES)
- Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (ES)
- Hospital Clínic de Barcelona (ES)
- Department of Embryology (US)
- Chengdu University (CN)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2024-08-26
- DOI
- https://doi.org/10.1186/s13287-024-03883-1
- Citations
- 4
- Primary Topic
- Congenital Diaphragmatic Hernia Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.29
Funders
- AstraZeneca
- European Commission
- Ministerio de Economía y Competitividad
- Universitat de Barcelona
- Sociedad Española de Neumología y Cirugía Torácica
- Agència de Gestió d'Ajuts Universitaris i de Recerca
- Faculty of Medicine and Health, University of Sydney