Pathological characteristics of axons and alterations of proteomic and lipidomic profiles in midbrain dopaminergic neurodegeneration induced by WDR45-deficiency
In this study, we uncovered the molecular mechanisms underlying the contribution of WDR45 deficiency to axonal degeneration, which involves complex relationships between phospholipid metabolism, autophagy, and tubular ER. These findings greatly advance our understanding of the fundamental molecular mechanisms driving axonal degeneration and may provide a foundation for developing novel mechanistically based therapeutic interventions for BPAN and other neurodegenerative diseases.
Authors
- Kunhyok Kim
- Weidong Le (ORCID: https://orcid.org/0000-0001-7459-2705)
- Yaping Shao (ORCID: https://orcid.org/0000-0002-2041-5479)
- Huaibin Cai (ORCID: https://orcid.org/0000-0002-8596-6108)
- Murad Al‐Nusaif (ORCID: https://orcid.org/0000-0001-7009-7555)
- Jun Zhang
- Cong Liu (ORCID: https://orcid.org/0000-0003-3425-6672)
- Panpan Wang (ORCID: https://orcid.org/0000-0003-4009-1456)
- Song Li (ORCID: https://orcid.org/0000-0003-2713-9136)
- Yuting Yang (ORCID: https://orcid.org/0000-0002-9421-7950)
- Huijia Yang
Institutions
- National Institutes of Health (US)
- Dalian Medical University (CN)
- Chinese Academy of Sciences (CN)
- Shanghai Institute of Organic Chemistry (CN)
- Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital (CN)
- National Institute on Aging (US)
- First Affiliated Hospital of Dalian Medical University (CN)
Publication Details
- Journal
- Molecular Neurodegeneration
- Published
- 2024-08-26
- DOI
- https://doi.org/10.1186/s13024-024-00746-4
- Citations
- 15
- Primary Topic
- Neurological diseases and metabolism
- Type
- article
- Field-Weighted Citation Impact
- 3.71
Funders
- Deutsches Krebsforschungszentrum
- National Natural Science Foundation of China
- Dalian Medical University
- National Institutes of Health
- Cambridge Institute for Medical Research, University of Cambridge