Antenatal steroids elicited neurodegenerative-associated transcriptional changes in the hippocampus of preterm fetal sheep independent of lung maturation
Our data suggests that exposure to antenatal steroid therapy is an independent cause of damage- associated transcriptomic changes in the brain of preterm, fetal sheep. These data highlight an urgent need for careful reconsideration and balancing of how antenatal steroids are used, both for patient selection and dosing regimens.
Authors
- Sebastián E. Illanes (ORCID: https://orcid.org/0000-0001-5433-9315)
- Gokce Oguz (ORCID: https://orcid.org/0000-0003-1044-7204)
- Erin L. Fee (ORCID: https://orcid.org/0000-0003-1240-8006)
- Yusaku Kumagai (ORCID: https://orcid.org/0000-0003-3253-9601)
- Masatoshi Saito (ORCID: https://orcid.org/0000-0001-8122-6623)
- Adaikalavan Ramasamy (ORCID: https://orcid.org/0000-0002-7598-2892)
- Alan H. Jobe (ORCID: https://orcid.org/0000-0003-3632-4114)
- Haruo Usuda (ORCID: https://orcid.org/0000-0002-9334-8086)
- Tsukasa Takahashi (ORCID: https://orcid.org/0000-0002-5567-4091)
- Mahesh Choolani (ORCID: https://orcid.org/0000-0001-8336-0973)
- Sean W. D. Carter (ORCID: https://orcid.org/0009-0000-3441-3186)
- Xia-Wen Liu
- Biswas Agnihotri
- Yuki Takahashi
- Zubair Amin (ORCID: https://orcid.org/0000-0002-4430-5012)
- Citra Nurfarah Zaini Mattar (ORCID: https://orcid.org/0000-0003-0068-6957)
- Wei Qin (ORCID: https://orcid.org/0000-0003-2161-387X)
- Hideyuki Ikeda (ORCID: https://orcid.org/0009-0005-0707-6125)
- Matthew W. Kemp (ORCID: https://orcid.org/0000-0002-0869-1710)
- Mark I. Evans
- Yuya Saito
Institutions
- Agency for Science, Technology and Research (SG)
- Cincinnati Children's Hospital Medical Center (US)
- National University of Singapore (SG)
- The University of Western Australia (AU)
- Universidad de Los Andes, Chile (CL)
- Khoo Teck Puat Hospital (SG)
- Tohoku University Hospital (JP)
- Women and Infants Research Foundation (AU)
- Fetal Medicine Foundation of America (US)
- National University Health System (SG)
- Genome Institute of Singapore (SG)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- BMC Medicine
- Published
- 2024-08-26
- DOI
- https://doi.org/10.1186/s12916-024-03542-5
- Citations
- 13
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 5.45
Funders
- National University of Singapore
- Government of Western Australia
- Stan Perron Charitable Foundation
- Medical Research Council
- National Health and Medical Research Council