A Phase III Randomized Controlled Trial of Plitidepsin, a Marine-Derived Compound, in Hospitalized Adults With Moderate COVID-19

Despite the trial limitations, these results suggest that plitidepsin may have a positive benefit-risk ratio in the management of patients requiring oxygen therapy. Further studies with plitidepsin, including those in immunosuppressed patients, are warranted.Results from this phase III trial suggest that plitidepsin, a first-in-class antiviral, may have a positive benefit-risk ratio in the management of hospitalized patients requiring oxygen therapy for moderate COVID-19.

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Publication Details

Journal
Clinical Infectious Diseases
Published
2024-08-26
DOI
https://doi.org/10.1093/cid/ciae227
Citations
14
Primary Topic
Respiratory Support and Mechanisms
Type
article
Field-Weighted Citation Impact
5.87
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article

A Phase III Randomized Controlled Trial of Plitidepsin, a Marine-Derived Compound, in Hospitalized Adults With Moderate COVID-19

Garyphallia Poulakou, Vicente Estrada, José Miguel Cisneros, Jesús Fortün et al.
14 citations
Clinical Infectious Diseases
Respiratory Support and Mechanisms
5.87
article

A Phase III Randomized Controlled Trial of Plitidepsin, a Marine-Derived Compound, in Hospitalized Adults With Moderate COVID-19

Garyphallia Poulakou, Vicente Estrada, José Miguel Cisneros, Jesús Fortün, Fernanda Meira, Pedro Landete, Esperanza Merino, Pérez Rodríguez, Diego López-Mendoza, Liliana Preoțescu, Eduardo Pérez-Alba, Pablo Ryan, Miguel Marcos, Adrien Lemaignen, Pablo Guisado‐Vasco, María Molina‐Molina, María del Carmen Fariñas-Álvarez, Αnastasia Kotanidou, Olga Adriana Căliman-Sturdza, Javier Gómez, José F. Varona, Carmen Hidalgo-Tenorio, Miguel Torralba, José A. López-Martín, Paula Villares, Dimitar Raev, Nadia Torres, Roger Paredes, Paula Patricia García-Ocaña, José Jimeno, Elena-Maria Saiz-Lou, Mihaela-Cătălina Luca, Shirley-Patricia Iglesias
article en
14 citations

Abstract

Despite the trial limitations, these results suggest that plitidepsin may have a positive benefit-risk ratio in the management of patients requiring oxygen therapy. Further studies with plitidepsin, including those in immunosuppressed patients, are warranted.Results from this phase III trial suggest that plitidepsin, a first-in-class antiviral, may have a positive benefit-risk ratio in the management of hospitalized patients requiring oxygen therapy for moderate COVID-19.

Clinical Infectious DiseasesVol. 79(4)
Ştefan cel Mare University of Suceava (RO), Universidad de Cantabria (ES), Carol Davila University of Medicine and Pharmacy (RO), Universidad Autónoma de Nuevo León (MX), National and Kapodistrian University of Athens (GR), Bellvitge University Hospital (ES), University Hospital Complex Of Vigo (ES), Hospital Clínico San Carlos (ES), Grigore T. Popa University of Medicine and Pharmacy (RO), IrsiCaixa (ES), Institut d'Investigació Biomédica de Bellvitge (ES), Spitalul Clinic C.F. Iasi (RO), Hospital Universitario de Guadalajara (ES), Centre Hospitalier Universitaire de Tours (FR), Complejo Hospitalario de Salamanca (ES), Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (ES), Marqués de Valdecilla University Hospital (ES), Hospital Universitario Quirónsalud Madrid (ES), University of the Coast (CO), Instituto de Investigación Marqués de Valdecilla (ES), Hospital Universitario Virgen de las Nieves (ES), PharmaMar (Spain) (ES), Hospital Civil de Guadalajara (MX), HM Hospitales (ES), Hospital Universitario de La Princesa (ES), Hospital Universitario Dr José Eleuterio Gonzalez (MX), Instituto de Biomedicina de Sevilla (ES), Spitalul Clinic de Urgenta Sfantul Ioan (RO), Hospital Universitario HM Sanchinarro (ES), Hospital General Universitario de Alicante Doctor Balmis (ES), Complexo Hospitalario Universitario A Coruña (ES), Hospital Universitario Virgen del Rocío (ES), Hospital Universitari Germans Trias i Pujol (ES), Hospital Jerez Puerta del Sur (ES), Hospital Universitario Ramón y Cajal (ES), Hospital Universitario Infanta Leonor (ES), Evangelismos Hospital (GR), Sotiria General Hospital (GR), Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL) (ES), Camilo José Cela University (ES), Universidad Autónoma de Madrid (ES), Universidad Europea de Madrid (ES)
Life below water
Openalex Percentile: Top 3%
Respiratory Support and Mechanisms
5.87
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