A Phase III Randomized Controlled Trial of Plitidepsin, a Marine-Derived Compound, in Hospitalized Adults With Moderate COVID-19
Despite the trial limitations, these results suggest that plitidepsin may have a positive benefit-risk ratio in the management of patients requiring oxygen therapy. Further studies with plitidepsin, including those in immunosuppressed patients, are warranted.Results from this phase III trial suggest that plitidepsin, a first-in-class antiviral, may have a positive benefit-risk ratio in the management of hospitalized patients requiring oxygen therapy for moderate COVID-19.
Authors
- Garyphallia Poulakou (ORCID: https://orcid.org/0000-0003-0778-0006)
- Vicente Estrada (ORCID: https://orcid.org/0000-0002-7795-5986)
- José Miguel Cisneros (ORCID: https://orcid.org/0000-0001-5001-672X)
- Jesús Fortün (ORCID: https://orcid.org/0000-0002-6959-5263)
- Fernanda Meira (ORCID: https://orcid.org/0000-0002-5096-4823)
- Pedro Landete (ORCID: https://orcid.org/0000-0002-9631-9408)
- Esperanza Merino (ORCID: https://orcid.org/0000-0003-3854-4874)
- Pérez Rodríguez (ORCID: https://orcid.org/0000-0003-2944-8610)
- Diego López-Mendoza
- Liliana Preoțescu (ORCID: https://orcid.org/0000-0002-3328-4789)
- Eduardo Pérez-Alba (ORCID: https://orcid.org/0000-0002-6642-2770)
- Pablo Ryan (ORCID: https://orcid.org/0000-0002-4212-7419)
- Miguel Marcos (ORCID: https://orcid.org/0000-0003-1269-4487)
- Adrien Lemaignen (ORCID: https://orcid.org/0000-0001-5974-5689)
- Pablo Guisado‐Vasco (ORCID: https://orcid.org/0000-0003-3019-4398)
- María Molina‐Molina (ORCID: https://orcid.org/0000-0002-1852-1723)
- María del Carmen Fariñas-Álvarez
- Αnastasia Kotanidou (ORCID: https://orcid.org/0000-0002-2508-500X)
- Olga Adriana Căliman-Sturdza (ORCID: https://orcid.org/0000-0003-2274-6439)
- Javier Gómez (ORCID: https://orcid.org/0000-0001-8058-2511)
- José F. Varona (ORCID: https://orcid.org/0000-0003-4764-9440)
- Carmen Hidalgo-Tenorio (ORCID: https://orcid.org/0000-0002-6394-5728)
- Miguel Torralba (ORCID: https://orcid.org/0000-0003-2166-7405)
- José A. López-Martín (ORCID: https://orcid.org/0000-0001-7530-3207)
- Paula Villares (ORCID: https://orcid.org/0000-0001-8389-8036)
- Dimitar Raev
- Nadia Torres (ORCID: https://orcid.org/0000-0003-1356-1344)
- Roger Paredes (ORCID: https://orcid.org/0000-0002-6553-691X)
- Paula Patricia García-Ocaña
- José Jimeno (ORCID: https://orcid.org/0009-0004-1095-1990)
- Elena-Maria Saiz-Lou
- Mihaela-Cătălina Luca
- Shirley-Patricia Iglesias
Institutions
- Ştefan cel Mare University of Suceava (RO)
- Universidad de Cantabria (ES)
- Carol Davila University of Medicine and Pharmacy (RO)
- Universidad Autónoma de Nuevo León (MX)
- National and Kapodistrian University of Athens (GR)
- Bellvitge University Hospital (ES)
- University Hospital Complex Of Vigo (ES)
- Hospital Clínico San Carlos (ES)
- Grigore T. Popa University of Medicine and Pharmacy (RO)
- IrsiCaixa (ES)
- Institut d'Investigació Biomédica de Bellvitge (ES)
- Spitalul Clinic C.F. Iasi (RO)
- Hospital Universitario de Guadalajara (ES)
- Centre Hospitalier Universitaire de Tours (FR)
- Complejo Hospitalario de Salamanca (ES)
- Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (ES)
- Marqués de Valdecilla University Hospital (ES)
- Hospital Universitario Quirónsalud Madrid (ES)
- University of the Coast (CO)
- Instituto de Investigación Marqués de Valdecilla (ES)
- Hospital Universitario Virgen de las Nieves (ES)
- PharmaMar (Spain) (ES)
- Hospital Civil de Guadalajara (MX)
- HM Hospitales (ES)
- Hospital Universitario de La Princesa (ES)
- Hospital Universitario Dr José Eleuterio Gonzalez (MX)
- Instituto de Biomedicina de Sevilla (ES)
- Spitalul Clinic de Urgenta Sfantul Ioan (RO)
- Hospital Universitario HM Sanchinarro (ES)
- Hospital General Universitario de Alicante Doctor Balmis (ES)
- Complexo Hospitalario Universitario A Coruña (ES)
- Hospital Universitario Virgen del Rocío (ES)
- Hospital Universitari Germans Trias i Pujol (ES)
- Hospital Jerez Puerta del Sur (ES)
- Hospital Universitario Ramón y Cajal (ES)
- Hospital Universitario Infanta Leonor (ES)
- Evangelismos Hospital (GR)
- Sotiria General Hospital (GR)
- Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL) (ES)
- Camilo José Cela University (ES)
- Universidad Autónoma de Madrid (ES)
- Universidad Europea de Madrid (ES)
Publication Details
- Journal
- Clinical Infectious Diseases
- Published
- 2024-08-26
- DOI
- https://doi.org/10.1093/cid/ciae227
- Citations
- 14
- Primary Topic
- Respiratory Support and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 5.87