Suppressed HIV antibody responses following exposure to antiretrovirals—evidence from PrEP randomized trials and early antiretroviral treatment initiation studies
PrEP and early ART initiation can delay or reduce HIV detectability. Considerations for the implementation of NAT and Ag/Ab tests in PrEP/PEP programs relying on Ab-only RDTs should be balanced according to feasibility and public health impact. While blood transfusion services using Ab-only RDTs for HIV screening should adopt higher sensitivity tests, surveillance and further research are needed to determine the need for novel HIV testing algorithms for those already using NAT and Ag/Ab screening assays.
Authors
- Jairam R. Lingappa (ORCID: https://orcid.org/0000-0001-6191-9828)
- Steven H Kleinman (ORCID: https://orcid.org/0000-0002-1638-2969)
- Vivian I. Avelino‐Silva (ORCID: https://orcid.org/0000-0002-6660-3088)
- Shelley N. Facente (ORCID: https://orcid.org/0000-0002-7266-352X)
- Robert M. Grant (ORCID: https://orcid.org/0000-0002-0851-7085)
- David J. Wright (ORCID: https://orcid.org/0000-0001-8666-4155)
- Sandhya Vasan (ORCID: https://orcid.org/0000-0002-6378-6288)
- Siriwat Akapirat (ORCID: https://orcid.org/0000-0001-6657-0960)
- Eduard Grebe (ORCID: https://orcid.org/0000-0001-7046-7245)
- Brian Custer (ORCID: https://orcid.org/0000-0001-6251-366X)
- Mark de Souza (ORCID: https://orcid.org/0000-0002-9953-0938)
- Philip J. Norris (ORCID: https://orcid.org/0000-0003-0526-2088)
- Nittaya Phanuphak (ORCID: https://orcid.org/0000-0002-0036-3165)
- Carlo Sacdalan (ORCID: https://orcid.org/0000-0002-5839-4837)
- Mars Stone (ORCID: https://orcid.org/0000-0001-5619-2767)
- Megha Mehrotra (ORCID: https://orcid.org/0000-0003-1748-8690)
- Michael Paul Busch (ORCID: https://orcid.org/0000-0002-1446-125X)
- Clara Di Germanio (ORCID: https://orcid.org/0000-0002-6047-211X)
- Patricia A. Defechereux
- Michael Schmidt (ORCID: https://orcid.org/0000-0001-9338-0900)
- Xutao Deng (ORCID: https://orcid.org/0000-0002-7372-3758)
- Sonia Bakkour
- Ashtyn L Conway
Institutions
- Henry M. Jackson Foundation (US)
- Gladstone Institutes (US)
- Westat (United States) (US)
- University of British Columbia (CA)
- Chulalongkorn University (TH)
- University of California, San Francisco (US)
- University of Washington (US)
- Bloodworks Northwest (US)
- German Red Cross (DE)
- Pacific Research Institute (US)
- Armed Forces Research Institute of Medical Science (TH)
- HIV Netherlands Australia Thailand Research Collaboration (TH)
- Bangkok University (TH)
Publication Details
- Journal
- International Journal of Infectious Diseases
- Published
- 2024-08-25
- DOI
- https://doi.org/10.1016/j.ijid.2024.107222
- Citations
- 15
- Primary Topic
- HIV/AIDS Research and Interventions
- Type
- article
- Field-Weighted Citation Impact
- 5.84
Funders
- U.S. Department of Defense
- Henry M. Jackson Foundation
- Gilead Sciences
- ViiV Healthcare
- Grifols
- National Institutes of Health
- National Heart, Lung, and Blood Institute
- National Institute of Allergy and Infectious Diseases