Ethical preparedness of data monitoring committees (DMCs) to oversee international clinical trials: a qualitative descriptive study
This study is one of the first to consider the ethical implications of DMC structure, membership and deliberations. The potential overuse of DMCs, DMC member recruitment processes that seem somewhat insular, limited training for DMC members, and divergent approaches to deliberation may limit the capacity of DMCs for addressing ethical issues. Further research on DMC structure and processes could help enhance the ethical preparedness of DMCs.
Authors
- Annette Rid (ORCID: https://orcid.org/0000-0003-1117-1975)
- Alex Hinga (ORCID: https://orcid.org/0000-0003-3427-1848)
- Seema Shah (ORCID: https://orcid.org/0000-0001-7726-1186)
- Lisa Eckstein (ORCID: https://orcid.org/0000-0002-7161-7521)
- Dorcas Kamuya (ORCID: https://orcid.org/0000-0001-7107-1736)
- Akram Ibrahim
- Diego Vintimilla
- Mickayla Jones
Institutions
- Northwestern University (US)
- University of Tasmania (AU)
- Chicago Department of Public Health (US)
- Kenya Medical Research Institute (KE)
- University of Oxford (GB)
- Lurie Children's Hospital (US)
- Fogarty International Center (US)
Publication Details
- Journal
- BMJ Global Health
- Published
- 2024-08-01
- DOI
- https://doi.org/10.1136/bmjgh-2024-015233
- Citations
- 1
- Primary Topic
- Ethics in Clinical Research
- Type
- article
- Field-Weighted Citation Impact
- 0.54
Funders
- U.S. Department of Health and Human Services
- Greenwall Foundation
- Wellcome Trust
- National Institutes of Health
- NIH Clinical Center