Comprehensive biomarker analysis of metabolomics in different syndromes in traditional Chinese medical for prediabetes mellitus
Our results revealed PreDM patients with different TCM syndromes were characterized by different clinical profiles. Common metabolite markers associated with PreDM shared by the two TCM syndromes were mainly lipid species encompassing GP, GL, cholesterol and derivatives. Our findings were in line with the current view that altered lipid metabolism is a conserved and early event of dysglycaemia. Our study also implied the possible involvement of perturbed bile acid homeostasis and dysregulated PE methylation during development of dysglycaemia.
Authors
- Caiyun Yang (ORCID: https://orcid.org/0000-0002-0521-4230)
- Jian-He Fang
- Xinyu Yu (ORCID: https://orcid.org/0000-0002-3689-980X)
- Zhanxuan E. Wu
- Hui Jian (ORCID: https://orcid.org/0009-0001-8335-1898)
- Xue Li (ORCID: https://orcid.org/0000-0003-4836-7808)
- Lan Qin (ORCID: https://orcid.org/0000-0001-5997-0480)
- Fei Li (ORCID: https://orcid.org/0000-0003-0490-7411)
Institutions
- Jiangxi University of Traditional Chinese Medicine (CN)
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2024-08-25
- DOI
- https://doi.org/10.1186/s13020-024-00983-1
- Citations
- 4
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.94