Therapeutic Drug Monitoring of Long-Acting Rilpivirine and Cabotegravir for Treatment of HIV-1 Infection—A Case Series of Five Patients With One Virologic Failure After Development of Two-Class Resistance
Virologic failure of long-acting rilpivirine/cabotegravir is rare but may result in severely limited treatment options. Known risk factors cannot predict all cases. Therapeutic drug monitoring (TDM) may help identify patients at risk, but reliable thresholds are missing. We report retrospective TDM in a cohort of 5 patients, including 1 virological failure.
Authors
- Amrei von Braun (ORCID: https://orcid.org/0000-0002-4335-8884)
- Michael Baier (ORCID: https://orcid.org/0000-0002-3625-1544)
- Ulrich Seybold (ORCID: https://orcid.org/0000-0001-9830-8350)
- Jacob Gerstenberg (ORCID: https://orcid.org/0009-0008-1604-9710)
- Christoph Stephan (ORCID: https://orcid.org/0000-0003-3777-9006)
- Hartwig Klinker (ORCID: https://orcid.org/0000-0001-7140-6786)
- Benjamin T. Schleenvoigt (ORCID: https://orcid.org/0000-0003-4678-2469)
- Klaus Korn (ORCID: https://orcid.org/0000-0003-1891-2107)
- Martin Däumer
- Carlotta Helbig
Institutions
- Goethe University Frankfurt (DE)
- University of Kaiserslautern (DE)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- University of Würzburg (DE)
- University Medical Center (US)
- LMU Klinikum (DE)
- Universitätsklinikum Erlangen (DE)
- University Hospital Leipzig (DE)
- University Hospital Frankfurt (DE)
- Jena University Hospital (DE)
- Friedrich Schiller University Jena (DE)
- University of Tübingen (DE)
- Ludwig-Maximilians-Universität München (DE)
- Leipzig University (DE)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2024-08-23
- DOI
- https://doi.org/10.1093/ofid/ofae480
- Citations
- 7
- Primary Topic
- HIV/AIDS drug development and treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.72
Funders
- Amgen
- Pfizer
- AstraZeneca
- Sanofi
- OPEC Fund for International Development
- Gilead Sciences
- ViiV Healthcare
- Deutsche Forschungsgemeinschaft
- Shionogi
- Seqirus
- Cilag