A fluorescent complex with peptide nucleic acids modified by boronic acid and its ligand detects target RNA in cells
Abstract We have developed peptide nucleic acids (PNAs) modified with boronic acid (Boa) and its ligand 2-(pyridin-2-yl)phenol (Pyp) as a probe for fluorescence detection of a target nucleic acid. Boa and Pyp successfully showed fluorescence by complexing via hybridization with PNA and the target. This fluorescent PNA probe also successfully responded to the target RNA in cells.
Authors
- Hajime Shigeto (ORCID: https://orcid.org/0000-0003-0602-8736)
- Mizuki Kitamatsu (ORCID: https://orcid.org/0000-0001-8643-8238)
- Koki Ishii
- Shohei Yamamura (ORCID: https://orcid.org/0000-0002-4971-4560)
- Yoshihide Hattori
Institutions
- Osaka Prefecture University (JP)
- Osaka Metropolitan University (JP)
- National Institute of Advanced Industrial Science and Technology (JP)
- Kindai University (JP)
Publication Details
- Journal
- Chemistry Letters
- Published
- 2024-08-23
- DOI
- https://doi.org/10.1093/chemle/upae169
- Citations
- 1
- Primary Topic
- Advanced biosensing and bioanalysis techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.23