Impact of proton versus photon adjuvant radiotherapy on overall survival in the management of skull base and spinal chordomas: a National Cancer Database analysis
Based on this nationwide analysis, patients with private insurance and higher income were more likely to receive proton adjuvant radiotherapy, while those with spinal or sacral chordomas were less likely to receive this modality. Despite this disparity, an OS benefit was observed in patients with chordomas of the spine and sacrum who received adjuvant proton therapy, in comparison with a matched cohort of patients treated with photon therapy. Conversely, this advantageous outcome was not evident in cases of chordomas located at the skull base.
Authors
- Ryan Huu-Tuan Nguyen (ORCID: https://orcid.org/0000-0002-8863-6649)
- Mohamad Bydon (ORCID: https://orcid.org/0000-0002-0543-396X)
- Abdul Karim Ghaith (ORCID: https://orcid.org/0000-0002-9600-609X)
- N. Saïdi (ORCID: https://orcid.org/0000-0003-4411-6147)
- Paul D. Brown (ORCID: https://orcid.org/0000-0003-0022-4533)
- Victor Gabriel El-Hajj (ORCID: https://orcid.org/0000-0001-9479-761X)
- Eric J. Lehrer (ORCID: https://orcid.org/0000-0002-1216-6230)
- Harry Hoang (ORCID: https://orcid.org/0009-0008-9096-5514)
- Adrian Elmi‐Terander (ORCID: https://orcid.org/0000-0002-3776-6136)
- Stephen P. Graepel (ORCID: https://orcid.org/0009-0005-5364-7929)
- Elias Atallah (ORCID: https://orcid.org/0000-0003-4206-5884)
Institutions
- Mayo Clinic (US)
- Thomas Jefferson University Hospital (US)
- WinnMed (US)
- Karolinska Institutet (SE)
- Neurological Surgery (US)
Publication Details
- Journal
- Journal of neurosurgery
- Published
- 2024-08-01
- DOI
- https://doi.org/10.3171/2024.5.jns24511
- Citations
- 4
- Primary Topic
- Bone Tumor Diagnosis and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.88