Pre–stereotactic radiosurgery neutrophil-to-lymphocyte ratio predicts post–stereotactic radiosurgery survival of patients with brain metastases concurrently treated with immune checkpoint inhibitors

The authors found elevated pre-SRS NLR (> 5) to be associated with shorter OS and IC-PFS after SRS with concurrent ICIs for BMs. NLR is a simple, cost-effective, and widely accessible biomarker, which can thus be used for managing patients with BMs receiving SRS concurrently with ICIs. Further investigation in other large datasets is, however, required to validate these findings.