Quantified Ataxic Breathing Can Detect Opioid-Induced Respiratory Depression Earlier in Normal Volunteers Infused with Remifentanil
AB was frequently present in the absence of traditionally detected OIRD as defined by reduced mental alertness (MOAA/S score of <4) and bradypnea (RR <8 breaths/min). These results justify the need for future trials to explore replicability with other opioids and clinical utility of AB as an add-on measure in recognizing OIRD.
Authors
- Sean Ermer
- Robert J. Farney
- Alan H. Morris (ORCID: https://orcid.org/0000-0001-7005-7924)
- Talmage D. Egan (ORCID: https://orcid.org/0000-0001-6583-9454)
- Lara Brewer (ORCID: https://orcid.org/0000-0002-6274-756X)
- Joseph Orr (ORCID: https://orcid.org/0000-0002-1892-0660)
- Ken B. Johnson (ORCID: https://orcid.org/0000-0003-2004-314X)
Institutions
- University of Utah (US)
Publication Details
- Journal
- Anesthesia & Analgesia
- Published
- 2024-08-23
- DOI
- https://doi.org/10.1213/ane.0000000000007124
- Citations
- 2
- Primary Topic
- Neuroscience of respiration and sleep
- Type
- article
- Field-Weighted Citation Impact
- 0.55