Phosphoglycerate Dehydrogenase Overexpression Inhibits Ferroptosis to Repress Calcification of Human Coronary Artery Vascular Smooth Muscle Cells via the P53/SLC7A11 Pathway
PHGDH overexpression suppresses the calcification level of HCASMCs by inhibiting ferroptosis through the P53/SLC7A11 signaling pathway, suggesting PHGDH as a promising therapeutic target of CAC.
Authors
- Dongdong Li (ORCID: https://orcid.org/0009-0005-5133-4478)
- Yuhai Zou
- Wenting Liu (ORCID: https://orcid.org/0000-0003-1461-3740)
- Ge Guan (ORCID: https://orcid.org/0000-0002-8943-2592)
Institutions
- Third Affiliated Hospital of Southern Medical University (CN)
- General Hospital of Guangzhou Military Command (CN)
- Guangzhou First People's Hospital (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- International Journal of General Medicine
- Published
- 2024-08-01
- DOI
- https://doi.org/10.2147/ijgm.s473908
- Citations
- 8
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 3.35