AGXT2 Suppresses the Proliferation and Dissemination of Hepatocellular Carcinoma Cells by Modulating Intracellular Lipid Metabolism
AGXT2 was found to lower cholesterol levels in liver cancer cells, possibly through interactions with the LDLR protein and modulation of PCSK9-mediated LDLR degradation. This mechanism may impede cholesterol transport to liver cancer cells, thereby suppressing their growth and metastasis.
Authors
- Tian Chen (ORCID: https://orcid.org/0009-0000-1023-1839)
- Weixian Chen (ORCID: https://orcid.org/0009-0005-5402-9567)
- Wenjin Zhang (ORCID: https://orcid.org/0009-0000-0515-8163)
- Lunjian Xiang
- Z.X. Xia (ORCID: https://orcid.org/0009-0002-3199-926X)
Institutions
- Chongqing University (CN)
- Dalian Medical University (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- Chongqing Three Gorges Central Hospital (CN)
- Chongqing Three Gorges University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Journal of Hepatocellular Carcinoma
- Published
- 2024-08-01
- DOI
- https://doi.org/10.2147/jhc.s470250
- Citations
- 4
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.14
Funders
- National Natural Science Foundation of China
- Chongqing University