Scientific evidence available after 18 years of application of fibrin rich in platelets and leukocytes in the repair of surgical wounds: An integrative review

Introduction: In the last 18 years, Platelet and Leukocyte Rich Fibrin (L-PRF) has emerged as an innovative biomaterial in regenerative medicine and dentistry, standing out for its ability to continuously release growth factors and promote more efficient healing. However, the variability in the preparation and application of L-PRF, together with the lack of standardization, represent major challenges, increasing the need for further research to improve and standardize its clinical use. Materials and Methods: This study is an integrative review, with no need to submit it to the Research Ethics Committee. The guiding question was: “What is the main evidence in the literature on the applications of platelet- and leukocyte-rich fibrin in dentistry?”. Results and Discussion: L-PRF has proved effective in various areas of dentistry. In implantology, it accelerates bone healing and improves implant integration. In periodontics, it promotes regeneration of bone damage and improves the quality of periodontal tissue. In gingival recessions and soft tissue lesions, it accelerates regeneration and reduces post-operative discomfort. In periodontal and maxillofacial surgery, it contributes to a faster and more comfortable recovery from swelling and pain. Variability in the preparation and application of L-PRF is still a challenge, and standardization of protocols is essential to ensure more consistent and predictable results. Conclusion: After 18 years, L-PRF has shown beneficial effects in dentistry, especially in terms of bone regeneration and improved post-operative healing. However, the standardization of protocols seems to be crucial in order to improve its clinical results.