Diet, Microbiome, and Inflammation Predictors of Fecal and Plasma Short-Chain Fatty Acids in Humans
These results suggest that resistant starch in the form of potatoes and microbially produced thiamine provide a substrate and essential cofactor, respectively, for butyrate synthesis. Thiamine may be a rate-limiting nutrient for butyrate production in adults. Overall, these findings illustrate the complex biology underpinning SCFA production in the gut. This trial was registered at clinicaltrials.gov as NCT02367287.
Authors
- Andrew Oliver
- Zeynep Alkan (ORCID: https://orcid.org/0000-0003-0454-418X)
- Charles B. Stephensen
- Danielle G. Lemay (ORCID: https://orcid.org/0000-0003-3318-0485)
- John W. Newman (ORCID: https://orcid.org/0000-0001-9632-6571)
- Mary E. Kable (ORCID: https://orcid.org/0000-0002-5485-6539)
Institutions
- Western Human Nutrition Research Center (US)
Publication Details
- Journal
- Journal of Nutrition
- Published
- 2024-08-20
- DOI
- https://doi.org/10.1016/j.tjnut.2024.08.012
- Citations
- 24
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 5.61
Funders
- U.S. Department of Energy
- U.S. Department of Agriculture
- National Institutes of Health
- Agricultural Research Service