A novel lncRNA GM47544 modulates triglyceride metabolism by inducing ubiquitination-dependent protein degradation of APOC3
The identification of GM47544 as a lncRNA modulator of ApoC3 reveals a novel mechanism of post-translational modification, with significant clinical implications for the treatment of hypertriglyceridemia and atherosclerosis.
Authors
- Luyun Wang (ORCID: https://orcid.org/0009-0003-7975-2693)
- Dao Wen Wang (ORCID: https://orcid.org/0000-0002-9774-3980)
- Qianqian Xiao (ORCID: https://orcid.org/0009-0006-5982-9368)
- Man Wang (ORCID: https://orcid.org/0000-0003-0859-3501)
- Jing Wang (ORCID: https://orcid.org/0000-0001-7199-4784)
- Hu Ding
Institutions
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2024-08-20
- DOI
- https://doi.org/10.1016/j.molmet.2024.102011
- Citations
- 4
- Primary Topic
- Lipid metabolism and disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China