Principles and New Strategies in Diabetic Foot Management

Background: Diabetic foot ulcers (DFU) occur in up to 15% of all diabetic patients and are a leading cause of nontraumatic amputation worldwide. DFUs require identifying the etiology and assessing the co-morbidities to provide the correct therapeutic approach, essential to reducing lower-extremity amputation risk.The high rates of therapy failure have resulted in the development of new therapies. Aim: Highlight the current trends in DFU management that could replace or complement the classical strategy for the management of DFU, as well as selective and targeted strategies that are needed to improve the healing process. Method: The authors, with precision, conducted an exhaustive literature search by thoroughly exploring the Science Direct, Scopus, PubMed, and Web of Science databases. They specifically sought out published studies and original articles that were featured in esteemed peer-reviewed journals and reported on original research. Conclusion: These new techniques are promising but still mostly unproven. New and generally more expensive therapies should be seen as adding to traditional approaches and not a replacement for conventional approaches.