New insight into the molecular mechanism of TCM Bufei Huoxue formula for chronic obstructive pulmonary disease based on network pharmacology and experimental verification
BHF provides a potent alternative for the treatment of COPD, and the mechanism is probably associated with regulating the PI3K/AKT pathway to alleviate inflammatory injury by bavachin, paeoniflorin, and demethylation of formononetin.
Authors
- Yubing Zhou (ORCID: https://orcid.org/0009-0007-2107-1843)
- Yuxian Lin (ORCID: https://orcid.org/0000-0003-1480-6593)
- Ting Luo (ORCID: https://orcid.org/0000-0002-9670-4031)
- Xuecun Liu
- Yuanying Zhu (ORCID: https://orcid.org/0000-0002-1410-3401)
- Hui Xu (ORCID: https://orcid.org/0000-0002-0136-4784)
- Yan Wu
- Shengyuan Hao
- Xin Yang (ORCID: https://orcid.org/0009-0002-6190-2588)
Institutions
- Yantai University (CN)
- Wenzhou Medical University (CN)
- Ruian People's Hospital (CN)
- Wenzhou City People's Hospital (CN)
Publication Details
- Journal
- Journal of Pharmacy and Pharmacology
- Published
- 2024-08-21
- DOI
- https://doi.org/10.1093/jpp/rgae071
- Primary Topic
- Natural product bioactivities and synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Yantai University
- British Heart Foundation
- Natural Science Foundation of Shandong Province